Genome-wide association study between copy number variants and hoof health traits in Holstein dairy cattle

Genome-wide association studies based on SNP have been completed for multiple traits in dairy cattle; however, copy number variants (CNV) could add genomic information that has yet to be harnessed. The objectives of this study were identify CNV genotyped Holstein animals and assess their with hoof health using deregressed estimated breeding values as pseudophenotypes. A total 23,256 comprising 1,645 regions identified 5,845 animals. Fourteen harboring structural variations, including 9 deletions 5 duplications, associated at least 1 the studied traits. This group included digital dermatitis, interdigital heel horn erosion, sole ulcer, white line lesion, hemorrhage, hyperplasia; no toe ulcer. Twenty candidate genes overlapped these SCART1, NRXN2, KIF26A, GPHN, OR7A17. In study, an effect infectious lesions attributed PRAME (Preferentially Expressed Antigen Melanoma) gene. Almost all detected noninfectious linked known metabolic disorders. knowledge obtained considering interest improve accuracy values. may further increase genetic gain Canadian population, thus reducing involuntary animal losses due lameness.